The method you use for getting the database handle doesn't matter, it can be threaded or non-threaded. You can use threaded
OR non-threaded queries on the returned handle. You do
not want to use both threaded and non-threaded queries on a single handle. If you need to use both threaded and non-threaded queries in your plugin then you will want to create two separate connections (one connection for purely threaded queries and the other for non-threaded queries).
See this post as well:
https://forums.alliedmods.net/showpo...3&postcount=16